Cellular Catabolism of the Iron-Regulatory Peptide Hormone Hepcidin

The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney.

It is generally accepted that iron homeostasis is mainly controlled in the gastrointestinal tract by absorption of dietary iron. However, recent studies have shown that the kidneys are also involved in iron metabolism. Since the iron-regulatory and antimicrobial peptide hormone hepcidin was originally isolated from human urine we have investigated the expression as well as the zonal and cellula...

Expression In Fish Of Hepcidin, A Putative Antimicrobial Peptide And Iron Regulatory Hormone

Hepcidin is a small, cationic peptide that was originally identified in mammals as an antimicrobial peptide and later shown to be an important iron regulatory hormone. Highly conserved hepcidin sequences have been identified in numerous fish species and there is evidence that the antimicrobial and iron-regulatory functions are conserved in fish as well. This review describes the expression of h...

The interactions and autoregulation of the iron regulatory peptide hormone hepcidin

IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin.

Hypoferremia is a common response to systemic infections or generalized inflammatory disorders. In mouse models, the development of hypoferremia during inflammation requires hepcidin, an iron regulatory peptide hormone produced in the liver, but the inflammatory signals that regulate hepcidin are largely unknown. Our studies in human liver cell cultures, mice, and human volunteers indicate that...

Hepcidin targets ferroportin for degradation in hepatocytes.

Hepcidin, a circulating regulatory hormone peptide produced by hepatocytes, functions as the master regulator of cellular iron export by controlling the amount of ferroportin, an iron exporter present on the basolateral surface of intestinal enterocytes and macrophages. Hepcidin binding to ferroportin induces its internalization and degradation, resulting in cellular iron retention and decrease...